Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis.

Blockade of the transient receptor potential channel vanilloid subfamily 1 (TRPV1) is suggested as a therapeutic approach to pain relief. However, TRPV1 is a widely expressed protein whose function might be critical in various nonneuronal physiologic conditions. The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is ...
overexpressed in many human epithelial cancers and is a potential target for anticancer drugs. Here, we show that TRPV1 interacts with EGFR, leading to EGFR degradation. Notably, the absence of TRPV1 in mice results in a striking increase in skin carcinogenesis. The TRPV1 is the first membrane receptor shown to have a tumor-suppressing effect associated with the down-regulation of another membrane receptor. The data suggest that, although a great deal of interest has focused on TRPV1 as a target for pain relief, the chronic blockade of this pain receptor might increase the risk for cancer development.
Mesh Terms:
Animals, Carcinogens, Cell Line, Tumor, Cell Transformation, Neoplastic, Down-Regulation, Lysosomes, Mice, Mice, Knockout, Protein Structure, Tertiary, Proto-Oncogene Proteins c-cbl, Receptor, Epidermal Growth Factor, Skin Neoplasms, TRPV Cation Channels, Tetradecanoylphorbol Acetate, Ubiquitin
Cancer Res.
Date: Feb. 01, 2009
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