c-Src is a PDZ interaction partner and substrate of the E3 ubiquitin ligase Ligand-of-Numb protein X1.

The very C-terminus of c-Src is a ligand for PDZ domains. In a screen for PDZ domains that interact with c-Src, we identified one of the PDZ domains of the Ligand-of-Numb protein X1 (LNX1), a multiple PDZ domain scaffold and RING type E3 ubiquitin ligase. We demonstrate that the interaction ...
of c-Src with LNX1 depends on the C-terminal PDZ ligand of c-Src. Furthermore, we show that c-Src phosphorylates LNX1. Moreover, c-Src itself is ubiquitinated by LNX1, suggesting an interdependent regulation of c-Src and LNX1.
Mesh Terms:
Cell Line, Humans, Ligands, PDZ Domains, Phosphorylation, Protein Interaction Mapping, Protein-Tyrosine Kinases, Substrate Specificity, Ubiquitin, Ubiquitin-Protein Ligases
FEBS Lett.
Date: Oct. 30, 2007
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