CCDC98 targets BRCA1 to DNA damage sites.
Breast cancer-1 (BRCA1) participates in the DNA damage response. However, the mechanism by which BRCA1 is recruited to DNA damage sites remains elusive. Recently, we have demonstrated that a ubiquitin-binding protein, RAP80, is required for DNA damage-induced BRCA1 translocation. Here we identify another component, CCDC98, in the BRCA1-RAP80 complex. CCDC98 ... mediates BRCA1's association with RAP80. Moreover, CCDC98 controls both DNA damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation. Together, our results demonstrate that CCDC98 is a BRCA1 binding partner that mediates BRCA1 function in response to DNA damage.
Mesh Terms:
BRCA1 Protein, Carrier Proteins, Cell Cycle, Cell Line, DNA Damage, DNA Repair, Humans, Nuclear Proteins, Protein Interaction Mapping, Protein Structure, Tertiary, Protein Transport, Signal Transduction
BRCA1 Protein, Carrier Proteins, Cell Cycle, Cell Line, DNA Damage, DNA Repair, Humans, Nuclear Proteins, Protein Interaction Mapping, Protein Structure, Tertiary, Protein Transport, Signal Transduction
Nat. Struct. Mol. Biol.
Date: Aug. 01, 2007
PubMed ID: 17643121
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