The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2.
Synthesis and maintenance of primary cilia are regulated by the von Hippel-Lindau (VHL) tumour suppressor protein. Recent studies indicate that this regulation is linked to microtubule-dependent functions of pVHL such as orienting microtubule growth and increasing plus-end microtubule stability, however little is known how this occurs. We have identified the ... kinesin-2 motor complex, known to regulate cilia, as a novel and endogenous pVHL binding partner. The interaction with kinesin-2 facilitates pVHL binding to microtubules. These data suggest that microtubule-dependent functions of pVHL are influenced by kinesin-2.
Mesh Terms:
Alleles, Animals, Cell Line, Humans, Kinesin, Mice, Microtubules, Mutation, Protein Binding, Von Hippel-Lindau Tumor Suppressor Protein
Alleles, Animals, Cell Line, Humans, Kinesin, Mice, Microtubules, Mutation, Protein Binding, Von Hippel-Lindau Tumor Suppressor Protein
FEBS Lett.
Date: Oct. 02, 2007
PubMed ID: 17825299
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