Identification of novel ARF binding proteins by two-hybrid screening.
The ARF tumor suppressor protects us against cancer through protein-protein interactions in partially defined p53-dependent and p53-independent pathways. We performed a two-hybrid screen using ARF as bait and present the identification of several new ARF partners that may regulate its growth inhibitory signaling. The potential physiological roles of these novel ... ARF binding proteins in regulating ARF signaling are discussed.
Mesh Terms:
Animals, COS Cells, Carrier Proteins, Cell Transformation, Neoplastic, Cercopithecus aethiops, Cyclin-Dependent Kinase Inhibitor p16, Growth Inhibitors, Humans, Mice, NIH 3T3 Cells, Protein Binding, Signal Transduction, Tumor Suppressor Protein p14ARF, Two-Hybrid System Techniques
Animals, COS Cells, Carrier Proteins, Cell Transformation, Neoplastic, Cercopithecus aethiops, Cyclin-Dependent Kinase Inhibitor p16, Growth Inhibitors, Humans, Mice, NIH 3T3 Cells, Protein Binding, Signal Transduction, Tumor Suppressor Protein p14ARF, Two-Hybrid System Techniques
Cell Cycle
Date: Mar. 01, 2006
PubMed ID: 16582619
View in: Pubmed Google Scholar
Download Curated Data For This Publication
143127
Switch View:
- Interactions 27