The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2.

CD27 is a lymphocyte-specific member of the TNF receptor (TNFR) family. It is a costimulatory molecule for peripheral T cells, as defined by its ability to enhance the TCR-induced proliferative response. We show here that CD27 augments TCR-induced Jun N-terminal kinase (JNK) activity in primary murine lymph node T cells. ...
To investigate how CD27 couples to JNK, we performed a yeast two hybrid screen with the CD27 cytoplasmic tail. This revealed that CD27 directly associates with Traf-2. Transfection experiments using dominant negative Traf-2 indicated that CD27 communicates with JNK via Traf-2. These findings group CD27 together with other members of the TNFR family, TNFR-1, -2, CD30 and CD40, which have all been shown to couple to Traf proteins. Since Traf proteins have been reported to initiate an anti-apoptotic signaling pathway, our data suggest that CD27 not only regulates proliferation, but also survival of T lymphocytes.
Mesh Terms:
Animals, Antigens, CD27, Apoptosis, COS Cells, JNK Mitogen-Activated Protein Kinases, MAP Kinase Kinase 4, Mice, Mice, Inbred C57BL, Mitogen-Activated Protein Kinase Kinases, Protein Kinases, Proteins, Receptors, Tumor Necrosis Factor, T-Lymphocytes, TNF Receptor-Associated Factor 2
Eur. J. Immunol.
Date: Jul. 01, 1998
Download Curated Data For This Publication
143816
Switch View:
  • Interactions 4