The AP-2 transcription factor is required for joint formation and cell survival in Drosophila leg development.
Flies mutant for the Drosophila homologue of the mammalian transcription factor AP-2 show a severe reduction in leg length and fail to develop joint structures. Presumptive joint cells express dAP-2 in response to Notch signaling. dAP-2 is required for joint cell differentiation and can induce formation of supernumerary joints when ... misexpressed. Although dAP-2 is expressed only in presumptive joint cells, its activity is required to support cell survival in the entire leg segment. Taken together, our data indicate that dAP-2 is an important mediator of Notch activity in leg development.
Mesh Terms:
Animals, Cell Survival, DNA-Binding Proteins, Drosophila, Drosophila Proteins, Extremities, Gene Expression, Joints, Membrane Proteins, Receptors, Notch, Transcription Factor AP-2, Transcription Factors
Animals, Cell Survival, DNA-Binding Proteins, Drosophila, Drosophila Proteins, Extremities, Gene Expression, Joints, Membrane Proteins, Receptors, Notch, Transcription Factor AP-2, Transcription Factors
Development
Date: Apr. 01, 2001
PubMed ID: 11262225
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