TNF receptor-associated factor 1 is a positive regulator of the NF-kappaB alternative pathway.

Dipartimento di Biologia e Patologia Cellulare e Molecolare, Federico II University of Naples, Naples, Italy.
Tumor necrosis factor receptor-associated factor 1 (TRAF1) is unique among the members of the TRAF family, as it lacks the N-terminal RING/zinc-finger domain. Also the function of TRAF1 is not clearly established, with many papers reporting contradictory results. Here we show that TRAF1 interacts with BAFF receptor, a member of the TNF receptor family, and positively regulates activation of the alternative NF-kappaB pathway. Ectopic expression of TRAF1 causes degradation of TRAF3, stabilization of NIK, and processing of p100 to produce the mature form p52. In addition, we show that knocking-down expression of TRAF1 in the Hodgkin's disease derived cell line L1236, interfere with p100 processing and with p52 mediate gene transcription. Collectively these results support a role for TRAF1 as a positive regulator of the NF-kappaB alternative pathway.
Mesh Terms:
B-Cell Activation Factor Receptor, Cell Line, Tumor, Gene Expression, Hodgkin Disease, Humans, NF-kappa B, Protein Stability, Protein-Serine-Threonine Kinases, TNF Receptor-Associated Factor 1, TNF Receptor-Associated Factor 3, Zinc Fingers
Mol. Immunol. Oct. 01, 2009; 46(16);3278-82 [PUBMED:19698991]
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