T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK(1).

Previous studies suggest that localization of tumor necrosis factor receptor (TNFR)-associated factor (TRAF) family members is important for regulating their signal transduction. During a screen for TRAF3-associated proteins that potentially alter TRAF3 subcellular localization and enable signal transduction, we identified a novel protein, T3JAM (TRAF3-interacting Jun N-terminal kinase (JNK)-activating modulator). ...
This protein associates specifically with TRAF3 but not other TRAF family members. Coexpression of T3JAM with TRAF3 recruits TRAF3 to the detergent-insoluble fraction. More importantly, T3JAM and TRAF3 synergistically activate JNK but not nuclear factor (NF)-kappaB. Our studies indicate that T3JAM may function as an adapter molecule that specifically regulates TRAF3-mediated JNK activation.
Mesh Terms:
Amino Acid Sequence, Animals, Cell Line, Enzyme Activation, Humans, JNK Mitogen-Activated Protein Kinases, Mice, Mice, Inbred C57BL, Microtubule-Associated Proteins, Mitogen-Activated Protein Kinases, Molecular Sequence Data, Organ Specificity, Protein Structure, Tertiary, Proteins, Receptors, Tumor Necrosis Factor, Sequence Homology, Amino Acid, Signal Transduction, Subcellular Fractions, Substrate Specificity, TNF Receptor-Associated Factor 3, Transfection, Two-Hybrid System Techniques
FEBS Lett.
Date: Oct. 23, 2003
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