The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins.
The 75 kDa tumor necrosis factor receptor (TNFR2) transduces extracellular signals via receptor-associated cytoplasmic proteins. Two of these signal transducers, TRAF1 and TRAF2, were isolated and characterized previously. We report here the biochemical purification and subsequent molecular cloning of two novel TNFR2-associated proteins, designated c-IAP1 and c-IAP2, that are closely ... related mammalian members of the inhibitor of apoptosis protein (IAP) family originally identified in baculoviruses. The viral and cellular IAPs contain N-terminal baculovirus IAP repeat (BIR) motifs and a C-terminal RING finger. The c-IAPs do not directly contact TNFR2, but rather associate with TRAF1 and TRAF2 through their N-terminal BIR motif-comprising domain. The recruitment of c-IAP1 or c-IAP2 to the TNFR2 signaling complex requires a TRAF2-TRAF1 heterocomplex.
Mesh Terms:
Animals, Apoptosis, Cell Cycle Proteins, Cell Line, Cloning, Molecular, Humans, Inhibitor of Apoptosis Proteins, Kidney, Mice, Molecular Sequence Data, Molecular Weight, Proteins, RNA, Messenger, Receptors, Tumor Necrosis Factor, Sequence Homology, Amino Acid, Signal Transduction, T-Lymphocytes, Cytotoxic, TNF Receptor-Associated Factor 1, TNF Receptor-Associated Factor 2, Viral Proteins
Animals, Apoptosis, Cell Cycle Proteins, Cell Line, Cloning, Molecular, Humans, Inhibitor of Apoptosis Proteins, Kidney, Mice, Molecular Sequence Data, Molecular Weight, Proteins, RNA, Messenger, Receptors, Tumor Necrosis Factor, Sequence Homology, Amino Acid, Signal Transduction, T-Lymphocytes, Cytotoxic, TNF Receptor-Associated Factor 1, TNF Receptor-Associated Factor 2, Viral Proteins
Cell
Date: Dec. 29, 1995
PubMed ID: 8548810
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