Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.
The Mdmx oncoprotein has only recently emerged as a critical-independent to Mdm2-regulator of p53 activation. We have determined the crystal structure of the N-terminal domain of human Mdmx bound to a 15-residue transactivation domain peptide of human p53. The structure shows why antagonists of the Mdm2 binding to p53 are ... ineffective in the Mdmx-p53 interaction.
Mesh Terms:
Humans, Models, Molecular, Mutant Proteins, Nuclear Proteins, Protein Binding, Protein Conformation, Protein Structure, Tertiary, Proto-Oncogene Proteins, Transcriptional Activation, Tumor Suppressor Protein p53
Humans, Models, Molecular, Mutant Proteins, Nuclear Proteins, Protein Binding, Protein Conformation, Protein Structure, Tertiary, Proto-Oncogene Proteins, Transcriptional Activation, Tumor Suppressor Protein p53
Cell Cycle
Date: Aug. 01, 2008
PubMed ID: 18677113
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