POSH2 is a RING finger E3 ligase with Rac1 binding activity through a partial CRIB domain.
The Plenty of SH3 domains protein (POSH) is an E3 ligase and a scaffold in the JNK mediated apoptosis, linking Rac1 to downstream components. We here describe POSH2 which was identified from a p21-activated kinase 2 (PAK2) interactor screen. POSH2 is highly homologous with other members of the POSH family; ... it contains four Src homology 3 (SH3) domains and a RING finger domain which confers E3 ligase activity to the protein. In addition POSH2 contains an N-terminal extension which is conserved among its mammalian counterparts. POSH2 interacts with GTP-loaded Rac1. We have mapped this interaction to a previously unrecognized partial Cdc42/Rac1-interactive binding domain.
Mesh Terms:
Amino Acid Sequence, Humans, Molecular Sequence Data, RING Finger Domains, Ubiquitin-Protein Ligases, cdc42 GTP-Binding Protein, rac1 GTP-Binding Protein
Amino Acid Sequence, Humans, Molecular Sequence Data, RING Finger Domains, Ubiquitin-Protein Ligases, cdc42 GTP-Binding Protein, rac1 GTP-Binding Protein
FEBS Lett.
Date: Sep. 24, 2010
PubMed ID: 20696164
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