Potassium channel regulator KCNRG regulates surface expression of Shaker-type potassium channels.
Besides their role in the generation of action potentials, voltage-gated potassium channels are implicated in cellular processes ranging from cell division to cell death. The K(+) channel regulator protein (KCNRG), identified as a putative tumor suppressor, reduces K(+) currents through human K(+) channels hKv1.1 and hKv1.4 expressed in Xenopus oocytes. ... Current attenuation requires the presence of the N-terminal T1 Domain and immunoprecipitation experiments suggest association of KCNRG with the N-terminus of the channel. Our data indicates that KCNRG is an ER-associated protein, which we propose regulates Kv1 family channel proteins by retaining a fraction of channels in endomembranes.
Mesh Terms:
Action Potentials, Animals, Cell Line, Cell Membrane, Endoplasmic Reticulum, Humans, Immunoprecipitation, Kv1.1 Potassium Channel, Kv1.4 Potassium Channel, Oocytes, Potassium Channels, Protein Structure, Tertiary, Xenopus
Action Potentials, Animals, Cell Line, Cell Membrane, Endoplasmic Reticulum, Humans, Immunoprecipitation, Kv1.1 Potassium Channel, Kv1.4 Potassium Channel, Oocytes, Potassium Channels, Protein Structure, Tertiary, Xenopus
Biochem. Biophys. Res. Commun.
Date: Jan. 15, 2010
PubMed ID: 19968958
View in: Pubmed Google Scholar
Download Curated Data For This Publication
145057
Switch View:
- Interactions 3