TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling.
The Toll/interleukin-1 receptor (TIR) family members play important roles in host defense. These receptors signal through TIR domain-containing adapter proteins. In this report, we identified a novel TIR domain-containing adapter protein designated as TIRP. Co-immunoprecipitation experiments suggest that TIRP is associated with IL-1 receptors. TIRP also interacts with kinase-inactive mutants ... of IRAK and IRAK-4, IRAK-2, IRAK-M, and TRAF6. Overexpression of TIRP activates NF-kappaB and potentiates IL-1 receptor-mediated NF-kappaB activation. A dominant negative mutant of TIRP inhibits IL-1- but not tumor necrosis factor-triggered NF-kappaB activation. Moreover, TIRP-mediated NF-kappaB activation is inhibited by dominant negative mutants of IRAK, IRAK-2, TRAF6, and IKKbeta. Our findings suggest that TIRP is involved in IL-1-triggered NF-kappaB activation and functions upstream of IRAK, IRAK-2, TRAF6, and IKKbeta
Mesh Terms:
Adaptor Proteins, Signal Transducing, Adaptor Proteins, Vesicular Transport, Amino Acid Sequence, Humans, Interleukin-1, Interleukin-1 Receptor-Associated Kinases, Membrane Glycoproteins, Molecular Sequence Data, Mutation, Protein Kinases, Protein Structure, Tertiary, Receptors, Cell Surface, Receptors, Interleukin, Receptors, Interleukin-1, Sequence Alignment, Signal Transduction, Toll-Like Receptors
Adaptor Proteins, Signal Transducing, Adaptor Proteins, Vesicular Transport, Amino Acid Sequence, Humans, Interleukin-1, Interleukin-1 Receptor-Associated Kinases, Membrane Glycoproteins, Molecular Sequence Data, Mutation, Protein Kinases, Protein Structure, Tertiary, Receptors, Cell Surface, Receptors, Interleukin, Receptors, Interleukin-1, Sequence Alignment, Signal Transduction, Toll-Like Receptors
J. Biol. Chem.
Date: Jul. 04, 2003
PubMed ID: 12721283
View in: Pubmed Google Scholar
Download Curated Data For This Publication
145275
Switch View:
- Interactions 6