Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein.

IL-2 is the major autocrine and paracrine growth factor produced by T cells upon T cell stimulation. The inducible expression of IL-2 is highly regulated by multiple transcription factors, particularly AP-1, which coordinately activate the promoter. Described here is the ability of the novel basic leucine zipper protein p21SNFT to ...
repress AP-1 activity and IL-2 transcription. A detailed analysis of the repression by p21SNFT repression on the IL-2 promoter distal NF-AT/AP-1 site demonstrates that it can bind DNA with NF-AT and Jun, strongly suggesting that it represses NF-AT/AP-1 activity by competing with Fos proteins for Jun dimerization. The importance of this repression is that p21SNFT inhibits the trans-activation potential of protein complexes that contain Jun, thereby demonstrating an additional level of control for the highly regulated, ubiquitous AP-1 transcription factor and the IL-2 gene.
Mesh Terms:
Basic-Leucine Zipper Transcription Factors, Binding Sites, DNA-Binding Proteins, Down-Regulation, Gene Expression Regulation, Humans, Interleukin-2, Jurkat Cells, Leucine Zippers, Lymphocyte Activation, Macromolecular Substances, Molecular Sequence Data, Molecular Weight, NFATC Transcription Factors, Nuclear Proteins, Promoter Regions, Genetic, Proto-Oncogene Proteins c-jun, Repressor Proteins, Transcription Factor AP-1, Transcription Factors, Transfection
J. Immunol.
Date: Jul. 15, 2000
Download Curated Data For This Publication
145786
Switch View:
  • Interactions 2