CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response.

The product of the breast cancer-1 gene, BRCA1, plays a crucial part in the DNA damage response through its interactions with many proteins, including BACH1, CtIP and RAP80. Here we identify a coiled-coil domain-containing protein, CCDC98, as a BRCA1-interacting protein. CCDC98 colocalizes with BRCA1 and is required for the formation ...
of BRCA1 foci in response to ionizing radiation. Moreover, like BRCA1, CCDC98 has a role in radiation sensitivity and damage-induced G2/M checkpoint control. Together, these results suggest that CCDC98 is a mediator of BRCA1 function involved in the mammalian DNA damage response.
Mesh Terms:
Amino Acid Motifs, BRCA1 Protein, Carrier Proteins, Cell Cycle, Cell Line, DNA Damage, DNA Repair, Humans, Protein Interaction Mapping, Protein Structure, Tertiary, Signal Transduction
Nat. Struct. Mol. Biol.
Date: Aug. 01, 2007
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