CAP (Cbl associated protein) regulates receptor-mediated endocytosis.

CAP (c-Cbl associated protein)/ponsin belongs to a family of adaptor proteins implicated in cell adhesion and signaling. Here we show that CAP binds to and co-localizes with the essential endocytic factor dynamin. We demonstrate that CAP promotes the formation of dynamin-decorated tubule like structures, which are also coated with actin ...
filaments. Accordingly, we found that the expression of CAP leads to the inhibition of dynamin-mediated endocytosis and increases EGFR stability. Thus, we suggest that CAP may coordinate the function of dynamin with the regulation of the actin cytoskeleton during endocytosis.
Mesh Terms:
Actins, Animals, COS Cells, Cercopithecus aethiops, Cytoskeleton, Dynamin II, Endocytosis, HeLa Cells, Humans, Immunoprecipitation, Microfilament Proteins, Rats
FEBS Lett.
Date: Jan. 22, 2009
Download Curated Data For This Publication
147553
Switch View:
  • Interactions 6