Three-dimensional structures of the TAFII-containing complexes TFIID and TFTC.
TBP (TATA-binding protein)-associated factors (TAF(II)s) are components of large multiprotein complexes such as TFIID, TFTC, STAGA, PCAF/GCN5, and SAGA, which play a key role in the regulation of gene expression by RNA polymerase II. The structures of TFIID and TFTC have been determined at 3.5-nanometer resolution by electron microscopy and ... digital image analysis of single particles. Human TFIID resembles a macromolecular clamp that contains four globular domains organized around a solvent-accessible groove of a size suitable to bind DNA. TFTC is larger and contains five domains, four of which are similar to TFIID.
Mesh Terms:
DNA-Binding Proteins, HeLa Cells, Humans, Image Processing, Computer-Assisted, Microscopy, Electron, Models, Molecular, Protein Conformation, Protein Folding, Protein Structure, Tertiary, TATA-Binding Protein Associated Factors, Transcription Factor TFIID, Transcription Factors, Transcription Factors, TFII
DNA-Binding Proteins, HeLa Cells, Humans, Image Processing, Computer-Assisted, Microscopy, Electron, Models, Molecular, Protein Conformation, Protein Folding, Protein Structure, Tertiary, TATA-Binding Protein Associated Factors, Transcription Factor TFIID, Transcription Factors, Transcription Factors, TFII
Science
Date: Dec. 10, 1999
PubMed ID: 10591645
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