Tubulin seeds alpha-synuclein fibril formation.
Increasing evidence suggests that alpha-synuclein is a common pathogenic molecule in several neurodegenerative diseases, particularly in Parkinson's disease. To understand alpha-synuclein pathology, we investigated molecules that interact with alpha-synuclein in human and rat brains and identified tubulin as an alpha-synuclein binding/associated protein. Tubulin co-localized with alpha-synuclein in Lewy bodies and ... other alpha-synuclein-positive pathological structures. Tubulin initiated and promoted alpha-synuclein fibril formation under physiological conditions in vitro. These findings suggest that an interaction between tubulin and alpha-synuclein might accelerate alpha-synuclein aggregation in diseased brains, leading to the formation of Lewy bodies.
Mesh Terms:
Amino Acid Sequence, Animals, Brain, Humans, Microscopy, Electron, Microtubules, Molecular Sequence Data, Nerve Tissue Proteins, Neurodegenerative Diseases, Rats, Synucleins, Tubulin, alpha-Synuclein
Amino Acid Sequence, Animals, Brain, Humans, Microscopy, Electron, Microtubules, Molecular Sequence Data, Nerve Tissue Proteins, Neurodegenerative Diseases, Rats, Synucleins, Tubulin, alpha-Synuclein
J. Biol. Chem.
Date: Jan. 18, 2002
PubMed ID: 11698390
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