A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A.
The adenoviral oncoprotein E1A induces progression through the cell cycle by binding to the products of the p300/CBP and retinoblastoma gene families. A new cellular p300/CBP-associated factor (P/CAF) having intrinsic histone acetylase activity has been identified that competes with E1A. Exogenous expression of P/CAF in HeLa cells inhibits cell-cycle progression ... and counteracts the mitogenic activity of E1A. E1A disturbs the normal cellular interaction between p300/CBP and its associated histone acetylase.
Mesh Terms:
Acetyltransferases, Adenovirus E1A Proteins, Amino Acid Sequence, Binding, Competitive, Cell Cycle, Cell Cycle Proteins, Cloning, Molecular, Escherichia coli, HeLa Cells, Histone Acetyltransferases, Humans, Molecular Sequence Data, Nuclear Proteins, Protein Binding, Recombinant Fusion Proteins, Saccharomyces cerevisiae Proteins, Sequence Deletion, Trans-Activators, Transcription Factors, p300-CBP Transcription Factors
Acetyltransferases, Adenovirus E1A Proteins, Amino Acid Sequence, Binding, Competitive, Cell Cycle, Cell Cycle Proteins, Cloning, Molecular, Escherichia coli, HeLa Cells, Histone Acetyltransferases, Humans, Molecular Sequence Data, Nuclear Proteins, Protein Binding, Recombinant Fusion Proteins, Saccharomyces cerevisiae Proteins, Sequence Deletion, Trans-Activators, Transcription Factors, p300-CBP Transcription Factors
Nature
Date: Jul. 25, 1996
PubMed ID: 8684459
View in: Pubmed Google Scholar
Download Curated Data For This Publication
149857
Switch View:
- Interactions 14