Role of focal adhesion kinase in MAP kinase activation by insulin-like growth factor-I or insulin.
Integrin-induced focal adhesion kinase (FAK) phosphorylation as well as insulin-like growth factor-I (IGF-I) and insulin activate MAP kinase. Since IGF-I or insulin have been suggested to affect FAK phosphorylation, we analyzed the role of FAK in IGF-I- or insulin-induced MAP kinase activation. Although MAP kinase was stimulated by IGF-I or ... insulin, FAK tyrosine phosphorylation remained unchanged in fibroblasts expressing normal or transiently elevated levels of IGF-I and insulin receptors. Further analysis in FAK deficient fibroblasts suggested that FAK impedes MAP kinase activation by IGF-I or insulin.
Mesh Terms:
Animals, Calcium-Calmodulin-Dependent Protein Kinases, Cell Adhesion Molecules, Cell Line, Enzyme Activation, Focal Adhesion Kinase 1, Focal Adhesion Protein-Tyrosine Kinases, Humans, Hypoglycemic Agents, Insulin, Insulin-Like Growth Factor I, Mice, Protein-Tyrosine Kinases
Animals, Calcium-Calmodulin-Dependent Protein Kinases, Cell Adhesion Molecules, Cell Line, Enzyme Activation, Focal Adhesion Kinase 1, Focal Adhesion Protein-Tyrosine Kinases, Humans, Hypoglycemic Agents, Insulin, Insulin-Like Growth Factor I, Mice, Protein-Tyrosine Kinases
FEBS Lett.
Date: Jul. 09, 1999
PubMed ID: 10431817
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