Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor.
The role of mitogen-activated protein (MAP) kinase cascades in integrating distinct upstream signals was studied in yeast. Mutants that were not able to activate PBS2 MAP kinase kinase (MAPKK; Pbs2p) at high osmolarity were characterized. Pbs2p was activated by two independent signals that emanated from distinct cell-surface osmosensors. Pbs2p was ... activated by MAP kinase kinase kinases (MAPKKKs) Ssk2p and Ssk22p that are under the control of the SLN1-SSK1 two-component osmosensor. Alternatively, Pbs2p was activated by a mechanism that involves the binding of its amino terminal proline-rich motif to the Src homology 3 (SH3) domain of a putative transmembrane osmosensor Sho1p.
Mesh Terms:
Amino Acid Sequence, Calcium-Calmodulin-Dependent Protein Kinases, Cloning, Molecular, Enzyme Activation, Fungal Proteins, Genes, Fungal, Intracellular Signaling Peptides and Proteins, MAP Kinase Kinase Kinases, Mitogen-Activated Protein Kinase Kinases, Mitogen-Activated Protein Kinases, Molecular Sequence Data, Mutation, Osmolar Concentration, Phosphorylation, Protein Kinases, Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Signal Transduction
Amino Acid Sequence, Calcium-Calmodulin-Dependent Protein Kinases, Cloning, Molecular, Enzyme Activation, Fungal Proteins, Genes, Fungal, Intracellular Signaling Peptides and Proteins, MAP Kinase Kinase Kinases, Mitogen-Activated Protein Kinase Kinases, Mitogen-Activated Protein Kinases, Molecular Sequence Data, Mutation, Osmolar Concentration, Phosphorylation, Protein Kinases, Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Signal Transduction
Science
Date: Jul. 28, 1995
PubMed ID: 7624781
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