Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2.
Cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Here we show that iNOS specifically binds to COX-2 and S-nitrosylates it, enhancing COX-2 catalytic activity. Selectively disrupting iNOS-COX-2 binding prevented NO-mediated activation of COX-2. This synergistic molecular interaction between two inflammatory systems may inform the development ... of anti-inflammatory drugs.
Mesh Terms:
Animals, Biotin, Catalysis, Cell Line, Cyclooxygenase 2, Cysteine, Dinoprostone, Enzyme Activation, Humans, Mice, Nitric Oxide Donors, Nitric Oxide Synthase Type II, Nitroso Compounds, Protein Binding, S-Nitrosoglutathione
Animals, Biotin, Catalysis, Cell Line, Cyclooxygenase 2, Cysteine, Dinoprostone, Enzyme Activation, Humans, Mice, Nitric Oxide Donors, Nitric Oxide Synthase Type II, Nitroso Compounds, Protein Binding, S-Nitrosoglutathione
Science
Date: Dec. 23, 2005
PubMed ID: 16373578
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