EG-1 interacts with c-Src and activates its signaling pathway.
EG-1 is significantly elevated in breast, colorectal, and prostate cancers. Overexpression of EG-1 stimulates cellular proliferation, and targeted inhibition blocks mouse xenograft tumor growth. To further clarify the function of EG-1, we investigated its role in c-Src activation. We observed that EG-1 overexpression results in activation of c-Src, but found ... no evidence that EG-1 is a direct Src substrate. EG-1 also binds to other members of the Src family. Furthermore, EG-1 shows interaction with multiple other SH3- and WW-containing molecules involved in various signaling pathways. These observations suggest that EG-1 may be involved in signaling pathways including c-Src activation.
Mesh Terms:
Cell Line, Tumor, Enzyme Activation, Humans, Neoplasms, Protein Interaction Mapping, Protein Structure, Tertiary, Proteins, Proto-Oncogene Proteins pp60(c-src), Signal Transduction, Transcriptional Activation, src Homology Domains
Cell Line, Tumor, Enzyme Activation, Humans, Neoplasms, Protein Interaction Mapping, Protein Structure, Tertiary, Proteins, Proto-Oncogene Proteins pp60(c-src), Signal Transduction, Transcriptional Activation, src Homology Domains
Int. J. Oncol.
Date: Oct. 01, 2006
PubMed ID: 16964398
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