Interactions between PBEF and oxidative stress proteins--a potential new mechanism underlying PBEF in the pathogenesis of acute lung injury.
Identification of pre-B-cell colony-enhancing factor (PBEF) interacting partners may reveal new molecular mechanisms of PBEF in the pathogenesis of acute lung injury (ALI). The interactions between PBEF and NADH dehydrogenase subunit 1(ND1), ferritin light chain and interferon induced transmembrane 3 (IFITM3) in human pulmonary vascular endothelial cells were identified and ... validated. ND1, ferritin and IFITM3 are involved in oxidative stress and inflammation. Overexpression of PBEF increased its interactions and intracellular oxidative stress, which can be attenuated by rotenone. The interaction modeling between PBEF and ND1 is consistent with the corresponding experimental finding. These interactions may underlie a novel role of PBEF in the pathogenesis of ALI.
Mesh Terms:
Amino Acid Sequence, Cytokines, Ferritins, Gene Library, Humans, Membrane Proteins, Molecular Sequence Data, NADH Dehydrogenase, Nicotinamide Phosphoribosyltransferase, Oxidative Stress, Protein Conformation, RNA-Binding Proteins, Respiratory Distress Syndrome, Adult, Two-Hybrid System Techniques
Amino Acid Sequence, Cytokines, Ferritins, Gene Library, Humans, Membrane Proteins, Molecular Sequence Data, NADH Dehydrogenase, Nicotinamide Phosphoribosyltransferase, Oxidative Stress, Protein Conformation, RNA-Binding Proteins, Respiratory Distress Syndrome, Adult, Two-Hybrid System Techniques
FEBS Lett.
Date: Jun. 11, 2008
PubMed ID: 18486613
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