Physical and functional interactions between hnRNP K and PRMT family proteins.
The mechanism underlying the protein-protein interaction of hnRNP K and PRMT family proteins is unclear. We examined and confirmed the arginine methylation of hnRNP K protein by PRMT1, not CARM1, via their direct binding. We also studied hnRNP K protein complexes containing CARM1, as well as PRMT1, using co-immunoprecipitation analysis. ... PRMT family proteins might be involved in the regulation of hnRNP K functions in nuclear receptor coactivator, transactivation, and p21 gene and protein expressions. We believe these observations will help provide insights into the regulation of hnRNP K protein functions via the recruitment of its associated proteins, including its arginine methylation-modifying proteins.
Mesh Terms:
Arginine, HeLa Cells, Heterogeneous-Nuclear Ribonucleoprotein K, Humans, Methylation, Protein Interaction Mapping, Protein-Arginine N-Methyltransferases, Repressor Proteins, Viral Core Proteins
Arginine, HeLa Cells, Heterogeneous-Nuclear Ribonucleoprotein K, Humans, Methylation, Protein Interaction Mapping, Protein-Arginine N-Methyltransferases, Repressor Proteins, Viral Core Proteins
FEBS Lett.
Date: Jan. 22, 2009
PubMed ID: 19101556
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