An RNA binding protein negatively controlling differentiation in fission yeast.
The fission yeast Schizosaccharomyces pombe starts sexual development when starved for nutrients and simultaneously activated by mating pheromones. We have identified a new gene regulating the onset of this process. This gene, called nrd1(+), encodes a typical RNA binding protein that preferentially binds poly(U). Deletion of nrd1(+) causes cells to ... initiate sexual development without nutrient starvation. We have found that the biological role of nrd1(+) is to block the onset of sexual development by repressing the Ste11-regulated genes essential for conjugation and meiosis until cells reach a critical level of starvation.
Mesh Terms:
Amino Acid Sequence, Base Sequence, Binding Sites, Calcium-Calmodulin-Dependent Protein Kinases, Carrier Proteins, Cell Differentiation, Culture Media, DNA, Fungal, Fungal Proteins, Gene Deletion, Genes, Fungal, Humans, Intracellular Signaling Peptides and Proteins, Mitogen-Activated Protein Kinase Kinases, Mitogen-Activated Protein Kinases, Molecular Sequence Data, Protein-Serine-Threonine Kinases, RNA-Binding Proteins, Ribonucleoproteins, Schizosaccharomyces, Schizosaccharomyces pombe Proteins, Sequence Homology, Amino Acid, Transcription Factors
Amino Acid Sequence, Base Sequence, Binding Sites, Calcium-Calmodulin-Dependent Protein Kinases, Carrier Proteins, Cell Differentiation, Culture Media, DNA, Fungal, Fungal Proteins, Gene Deletion, Genes, Fungal, Humans, Intracellular Signaling Peptides and Proteins, Mitogen-Activated Protein Kinase Kinases, Mitogen-Activated Protein Kinases, Molecular Sequence Data, Protein-Serine-Threonine Kinases, RNA-Binding Proteins, Ribonucleoproteins, Schizosaccharomyces, Schizosaccharomyces pombe Proteins, Sequence Homology, Amino Acid, Transcription Factors
Mol. Cell. Biol.
Date: Aug. 01, 1998
PubMed ID: 9671458
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