Fission yeast Csk1 is a CAK-activating kinase (CAKAK).
Cell cycle progression is dependent on the sequential activity of cyclin-dependent kinases (CDKs). For full activity, CDKs require an activating phosphorylation of a conserved residue (corresponding to Thr160 in human CDK2) carried out by the CDK-activating kinase (CAK). Two distinct CAK kinases have been described: in budding yeast Saccharomyces cerevisiae, ... the Cak1/Civ1 kinase is responsible for CAK activity. In several other species including human, Xenopus, Drosophila and fission yeast Schizosaccharomyces pombe, CAK has been identified as a complex homologous to CDK7-cyclin H (Mcs6-Mcs2 in fission yeast). Here we identify the fission yeast Csk1 kinase as an in vivo activating kinase of the Mcs6-Mcs2 CAK defining Csk1 as a CAK-activating kinase (CAKAK).
Mesh Terms:
Amino Acid Sequence, Cell Cycle, Conserved Sequence, Cyclin H, Cyclin-Dependent Kinases, Cyclins, Drosophila Proteins, Enzyme Activation, Gene Dosage, Genes, Suppressor, Phosphorylation, Protein Kinases, Protein-Serine-Threonine Kinases, Schizosaccharomyces, Schizosaccharomyces pombe Proteins
Amino Acid Sequence, Cell Cycle, Conserved Sequence, Cyclin H, Cyclin-Dependent Kinases, Cyclins, Drosophila Proteins, Enzyme Activation, Gene Dosage, Genes, Suppressor, Phosphorylation, Protein Kinases, Protein-Serine-Threonine Kinases, Schizosaccharomyces, Schizosaccharomyces pombe Proteins
EMBO J.
Date: Dec. 15, 1998
PubMed ID: 9857180
View in: Pubmed Google Scholar
Download Curated Data For This Publication
15336
Switch View:
- Interactions 4