The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic.

The specificity of intracellular vesicle transport is mediated in part by tethering factors that attach the vesicle to the destination organelle prior to fusion. We have identified a protein, Dor1p, that is involved in vesicle targeting to the yeast Golgi apparatus and found it to be associated with seven further ...
proteins. Identification of these revealed that they include Sec34p and Sec35p, the two known components of the Sec34/35 complex previously proposed to tether vesicles to the Golgi. Of the six previously uncharacterized components, four have homologs in higher eukaryotes, including a subunit of a mammalian Golgi transport complex. Furthermore, several of the proteins show distant homology to components of two other putative tethering complexes, the exocyst and the Vps52/53/54 complex, revealing that tethering factors involved in different membrane traffic steps are structurally related.
Mesh Terms:
Adaptor Proteins, Vesicular Transport, Animals, COS Cells, Carrier Proteins, Fungal Proteins, Golgi Apparatus, Humans, Membrane Proteins, Molecular Sequence Data, Mutation, Phenotype, Protein Transport, Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid, Vesicular Transport Proteins, Yeasts
Dev. Cell
Date: Oct. 01, 2001
Download Curated Data For This Publication
15435
Switch View:
  • Interactions 20