Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors.
Transforming growth factor beta (TGF beta) and activin each bind to pairs of membrane proteins, known as receptor types I and II, that associate to form a signaling complex. We report that TSR-I and ActR-I, two human transmembrane serine/threonine kinases distantly related to TGF beta and activin type II receptors, ... act as type I receptors for these factors. TSR-I is a type I receptor shared by TGF beta and activin, whereas ActR-I is an activin type I receptor. ActR-I, but not TSR-I, signals a particular transcriptional response in concert with activin type II receptors. The results indicate that type I receptors are transmembrane protein kinases that associate with type II receptors to generate diverse heteromeric serine/threonine kinase complexes of different signaling capacities.
Mesh Terms:
Activin Receptors, Activins, Cloning, Molecular, DNA Primers, DNA, Complementary, Gene Expression Regulation, Humans, Inhibins, Ligands, Macromolecular Substances, Molecular Sequence Data, Protein-Serine-Threonine Kinases, RNA, Messenger, Receptors, Cell Surface, Receptors, Growth Factor, Receptors, Transforming Growth Factor beta, Sequence Alignment, Sequence Homology, Amino Acid, Signal Transduction, Species Specificity, Transforming Growth Factor beta
Activin Receptors, Activins, Cloning, Molecular, DNA Primers, DNA, Complementary, Gene Expression Regulation, Humans, Inhibins, Ligands, Macromolecular Substances, Molecular Sequence Data, Protein-Serine-Threonine Kinases, RNA, Messenger, Receptors, Cell Surface, Receptors, Growth Factor, Receptors, Transforming Growth Factor beta, Sequence Alignment, Sequence Homology, Amino Acid, Signal Transduction, Species Specificity, Transforming Growth Factor beta
Cell
Date: Nov. 19, 1993
PubMed ID: 8242742
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