The mammalian RNA-binding protein Staufen2 links nuclear and cytoplasmic RNA processing pathways in neurons.
Members of the Staufen family of RNA-binding proteins are highly conserved cytoplasmic RNA transporters associated with RNA granules. staufen2 is specifically expressed in neurons where the delivery of RNA to dendrites is thought to have a role in plasticity. We found that Staufen2 interacts with the nuclear pore protein p62, ... with the RNA export protein Tap and with the exon-exon junction complex (EJC) proteins Y14-Mago. The interaction of Staufen2 with the Y14-Mago heterodimer seems to represent a highly conserved complex as the same proteins are involved in the Staufen-mediated localization of oskar mRNA in Drosophila oocytes. A pool of Staufen2 is present in neuronal nuclei and colocalizes to a large degree with p62 and partly with Tap, Y14, and Mago. We suggest a model whereby a set of conserved genes in the oskar mRNA export pathway may be recruited to direct a dendritic destination for mRNAs originating as a Staufen2 nuclear complex.
Mesh Terms:
Amino Acid Sequence, Animals, Cell Line, Cell Nucleus, Cloning, Molecular, Cytoplasm, DNA, Complementary, Gene Library, Humans, Molecular Sequence Data, Nerve Tissue Proteins, Neurons, Plasmids, RNA Processing, Post-Transcriptional, RNA-Binding Proteins, Rats, Saccharomyces cerevisiae, Sequence Alignment, Sequence Homology, Amino Acid, Transfection
Amino Acid Sequence, Animals, Cell Line, Cell Nucleus, Cloning, Molecular, Cytoplasm, DNA, Complementary, Gene Library, Humans, Molecular Sequence Data, Nerve Tissue Proteins, Neurons, Plasmids, RNA Processing, Post-Transcriptional, RNA-Binding Proteins, Rats, Saccharomyces cerevisiae, Sequence Alignment, Sequence Homology, Amino Acid, Transfection
Neuromolecular Med.
Date: Jun. 23, 2005
PubMed ID: 15970630
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