A DNA damage response pathway controlled by Tel1 and the Mre11 complex.
We define a DNA damage checkpoint pathway in S. cerevisiae governed by the ATM homolog Tel1 and the Mre11 complex. In mitotic cells, the Tel1-Mre11 complex pathway triggers Rad53 activation and its interaction with Rad9, whereas in meiosis it acts via Rad9 and the Rad53 paralog Mre4/Mek1. Activation of the ... Tel1-Mre11 complex pathway checkpoint functions appears to depend upon the Mre11 complex as a damage sensor and, at least in meiotic cells, to depend on unprocessed DNA double-strand breaks (DSBs). The DSB repair functions of the Mre11 complex are enhanced by the pathway, suggesting that the complex both initiates and is regulated by the Tel1-dependent DSB signal. These findings demonstrate that the diverse functions of the Mre11 complex in the cellular DNA damage response are conserved in mammals and yeast.
Mesh Terms:
Cell Cycle Proteins, DNA Damage, DNA Repair, DNA-Binding Proteins, Endodeoxyribonucleases, Exodeoxyribonucleases, Fungal Proteins, Genes, cdc, Intracellular Signaling Peptides and Proteins, Protein Kinases, Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae Proteins, Yeasts
Cell Cycle Proteins, DNA Damage, DNA Repair, DNA-Binding Proteins, Endodeoxyribonucleases, Exodeoxyribonucleases, Fungal Proteins, Genes, cdc, Intracellular Signaling Peptides and Proteins, Protein Kinases, Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae Proteins, Yeasts
Mol. Cell
Date: Jun. 01, 2001
PubMed ID: 11430828
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