The N-terminal acetylation of Sir3 stabilizes its binding to the nucleosome core particle.

The N-terminal acetylation of Sir3 is essential for heterochromatin establishment and maintenance in yeast, but its mechanism of action is unknown. The crystal structure of the N-terminally acetylated BAH domain of Saccharomyces cerevisiae Sir3 bound to the nucleosome core particle reveals that the N-terminal acetylation stabilizes the interaction of Sir3 ...
with the nucleosome. Additionally, we present a new method for the production of protein-nucleosome complexes for structural analysis.
Nat. Struct. Mol. Biol.
Date: Aug. 11, 2013
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