Yeast homologue of neuronal frequenin is a regulator of phosphatidylinositol-4-OH kinase.
In metazoans, certain calmodulin-related calcium-binding proteins (recoverins, neurocalcins and frequenins) are found at highest levels in excitable cells, but their physiological roles are largely uncharacterized. Here we show that Saccharomyces cerevisiae contains a frequenin homologue, Frq1, and that its target is Pik1, a phosphatidylinositol-4-OH kinase. Frq1 binds to a conserved ... sequence motif in Pik1 outside Pik1's catalytic domain and stimulates its activity in vitro. N-myristoylated Frq1 may also assist in Pik1 localization.
Mesh Terms:
1-Phosphatidylinositol 4-Kinase, Amino Acid Sequence, Animals, Binding Sites, Calcium-Binding Proteins, Conserved Sequence, Enzyme Activation, Fungal Proteins, Genes, Fungal, Molecular Sequence Data, Nerve Tissue Proteins, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid
1-Phosphatidylinositol 4-Kinase, Amino Acid Sequence, Animals, Binding Sites, Calcium-Binding Proteins, Conserved Sequence, Enzyme Activation, Fungal Proteins, Genes, Fungal, Molecular Sequence Data, Nerve Tissue Proteins, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid
Nat. Cell Biol.
Date: Aug. 01, 1999
PubMed ID: 10559922
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