The Rad52-Rad59 complex interacts with Rad51 and replication protein A.
The RAD52 gene is essential for homology-dependent repair of double-strand breaks in Saccharomyces cerevisiae. Rad52 forms complexes with Rad51, replication protein A (RPA) or Rad59 and its presence is essential for the formation of Rad51-Rad52-Rad59 and RPA-Rad52-Rad59 complexes. The N-terminal region of Rad52, which is required for self-interaction to form ... a ring structure, is required for interaction with Rad59. Rad59 also shows self-interaction suggesting the formation of heteromeric and homomeric rings of Rad52 and Rad59. In wild-type cells, we propose the Rad51-Rad52-Rad59 complex is involved in conservative recombination events, including gene conversion and reciprocal recombination, whereas the Rad52-Rad59 complex participates in single-strand annealing.
Mesh Terms:
Binding Sites, DNA, DNA Damage, DNA Repair, DNA Replication, DNA, Single-Stranded, DNA-Binding Proteins, Precipitin Tests, Protein Binding, Rad51 Recombinase, Rad52 DNA Repair and Recombination Protein, Recombination, Genetic, Replication Protein A, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins
Binding Sites, DNA, DNA Damage, DNA Repair, DNA Replication, DNA, Single-Stranded, DNA-Binding Proteins, Precipitin Tests, Protein Binding, Rad51 Recombinase, Rad52 DNA Repair and Recombination Protein, Recombination, Genetic, Replication Protein A, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins
DNA Repair (Amst.)
Date: Oct. 07, 2003
PubMed ID: 13679150
View in: Pubmed Google Scholar
Download Curated Data For This Publication
15828
Switch View:
- Interactions 9