Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion.
The DF3/MUC1 mucin-like glycoprotein is aberrantly overexpressed in human breast carcinomas. The functional role of DF3 is unknown. The present studies demonstrate that DF3 associates with beta-catenin. Similar findings have been obtained for gamma-catenin but not alpha-catenin. DF3, like E-cadherin and the adenomatous polyposis coli gene product, contains an SXXXXXSSL ... site that is responsible for direct binding to beta-catenin. The results further demonstrate that interaction of DF3 and beta-catenin is dependent on cell adhesion. These findings and the role of beta-catenin in cell signaling support a role for DF3 in the adhesion of epithelial cells.
Mesh Terms:
Adenomatous Polyposis Coli Protein, Antigens, Neoplasm, Breast Neoplasms, Cadherins, Cell Adhesion, Cytoskeletal Proteins, Female, Genes, APC, Humans, Mucin-1, Trans-Activators, Tumor Markers, Biological, beta Catenin
Adenomatous Polyposis Coli Protein, Antigens, Neoplasm, Breast Neoplasms, Cadherins, Cell Adhesion, Cytoskeletal Proteins, Female, Genes, APC, Humans, Mucin-1, Trans-Activators, Tumor Markers, Biological, beta Catenin
J. Biol. Chem.
Date: May. 09, 1997
PubMed ID: 9139698
View in: Pubmed Google Scholar
Download Curated Data For This Publication
1623
Switch View:
- Interactions 2