HDAC6 mediates the acetylation of TRIM50.
The E3 Ubiquitin ligase TRIM50 promotes the formation and clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction, a tubulin specific deacetylase that regulates microtubule-dependent aggresome formation. In this report we showed that TRIM50 is a target of HDAC6 with Lys-372 as a critical residue for acetylation. We identified p300 and ... PCAF as two TRIM50 acetyltransferases and we further showed that a balance between ubiquitination and acetylation regulates TRIM50 degradation.
Cell. Signal.
Date: Feb. 01, 2014
PubMed ID: 24308962
View in: Pubmed Google Scholar
Download Curated Data For This Publication
163556
Switch View:
- Interactions 4