c-erbB-2 gene product directly associates with beta-catenin and plakoglobin.
Association of the c-erbB-2 oncogene product with the cadherin-catenin complex has been demonstrated in human cancer cell lines. Although beta-catenin and plakoglobin have been proven to be crucial for the association, no previous study has shown whether the interactions are direct or indirect. In the present study, the c-erbB-2 gene ... product was shown by far-Western blotting analysis to associate directly with both beta-catenin and plakoglobin through its cytoplasmic domain core region, which showed extensive homology with epidermal growth factor receptor. These data suggest that c-erbB-2-induced signaling is also directly liked to the cadherin-mediated cell adhesion and "invasion-suppressor" system through beta-catenin and plakoglobin in cancers.
Mesh Terms:
Adenocarcinoma, Blotting, Western, Cadherins, Cell Adhesion Molecules, Cloning, Molecular, Cytoskeletal Proteins, Desmoplakins, Genes, erbB-2, Glutathione Transferase, Humans, Protein Binding, Receptor, Epidermal Growth Factor, Receptor, erbB-2, Recombinant Fusion Proteins, Sequence Homology, Amino Acid, Stomach Neoplasms, Trans-Activators, Tumor Cells, Cultured, beta Catenin, gamma Catenin
Adenocarcinoma, Blotting, Western, Cadherins, Cell Adhesion Molecules, Cloning, Molecular, Cytoskeletal Proteins, Desmoplakins, Genes, erbB-2, Glutathione Transferase, Humans, Protein Binding, Receptor, Epidermal Growth Factor, Receptor, erbB-2, Recombinant Fusion Proteins, Sequence Homology, Amino Acid, Stomach Neoplasms, Trans-Activators, Tumor Cells, Cultured, beta Catenin, gamma Catenin
Biochem. Biophys. Res. Commun.
Date: Mar. 28, 1995
PubMed ID: 7702605
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