SUMOylation of Blimp-1 promotes its proteasomal degradation.

B lymphocyte induced maturation protein-1 (Blimp-1) is a transcription repressor of the Krueppel-like family. Blimp-1 plays important roles in developmental processes, such as of germ cells and hair follicle stem cells. In B lymphocytes Blimp-1 orchestrates the terminal differentiation into plasma cells. We discovered that Blimp-1 undergoes SUMOylation by SUMO-1. ...
This SUMOylation is modulated by the SUMO protease SENP1. While Blimp-1 is relatively stable in 293T cells, a fusion with SUMO1 rendered it to rapid proteasomal degradation. Increase in SENP1 activity stabilized Blimp-1, while a decrease promoted its degradation. Our data indicate that SUMOylation of Blimp-1 regulates its intracellular stability.
Mesh Terms:
Cell Line, Endopeptidases, Humans, Proteasome Endopeptidase Complex, Protein Stability, Repressor Proteins, SUMO-1 Protein, Sumoylation
FEBS Lett.
Date: Aug. 04, 2011
Download Curated Data For This Publication
164841
Switch View:
  • Interactions 1
  • PTM Genes 1