TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1.).
The TRIM family of genes is largely studied because of their roles in development, differentiation and host cell antiviral defenses; however, roles in cancer biology are emerging. Loss of heterozygosity of the TRIM3 locus in ∼20% of human glioblastomas raised the possibility that this NHL-domain containing member of the TRIM ... gene family might be a mammalian tumor suppressor. Consistent with this, reducing TRIM3 expression increased the incidence of and accelerated the development of platelet-derived growth factor -induced glioma in mice. Furthermore, TRIM3 can bind to the cdk inhibitor p21(WAF1/CIP1). Thus, we conclude that TRIM3 is a tumor suppressor mapping to chromosome 11p15.5 and that it might block tumor growth by sequestering p21 and preventing it from facilitating the accumulation of cyclin D1-cdk4.
Mesh Terms:
Animals, Carrier Proteins, Cell Line, Cell Line, Transformed, Cell Line, Tumor, Cyclin-Dependent Kinase Inhibitor p21, Gene Expression Regulation, Neoplastic, Glioblastoma, Humans, Immunoblotting, Loss of Heterozygosity, Mice, Mice, Knockout, Mutation, Protein Binding, RNA Interference, RNA, Messenger, Tumor Suppressor Proteins
Animals, Carrier Proteins, Cell Line, Cell Line, Transformed, Cell Line, Tumor, Cyclin-Dependent Kinase Inhibitor p21, Gene Expression Regulation, Neoplastic, Glioblastoma, Humans, Immunoblotting, Loss of Heterozygosity, Mice, Mice, Knockout, Mutation, Protein Binding, RNA Interference, RNA, Messenger, Tumor Suppressor Proteins
Oncogene
Date: Jan. 16, 2014
PubMed ID: 23318451
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