Alpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress.
Alpha thalassemia/mental retardation syndrome X-linked (ATRX) is a member of the SWI/SNF protein family of DNA-dependent ATPases. It functions as a chromatin remodeler and is classified as an SNF2-like helicase. Here, we showed somatic knock-out of ATRX displayed perturbed S-phase progression as well as hypersensitivity to replication stress. ATRX is ... recruited to sites of DNA damage, required for efficient checkpoint activation and faithful replication restart. In addition, we identified ATRX as a binding partner of MRE11-RAD50-NBS1 (MRN) complex. Together, these results suggest a non-canonical function of ATRX in guarding genomic stability.
Mesh Terms:
Cell Cycle Proteins, DNA Damage, DNA Helicases, DNA Repair Enzymes, DNA Replication, DNA-Binding Proteins, Gene Knockdown Techniques, Genomic Instability, HeLa Cells, Humans, Multiprotein Complexes, Nuclear Proteins, S Phase
Cell Cycle Proteins, DNA Damage, DNA Helicases, DNA Repair Enzymes, DNA Replication, DNA-Binding Proteins, Gene Knockdown Techniques, Genomic Instability, HeLa Cells, Humans, Multiprotein Complexes, Nuclear Proteins, S Phase
J. Biol. Chem.
Date: Mar. 01, 2013
PubMed ID: 23329831
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