SIR2-induced inviability is suppressed by histone H4 overexpression.

We have identified histone H4 as a high-expression suppressor of Sir2-induced inviability in yeast cells. Overexpression of histone H3 does not suppress Sir2-induced lethality, nor does overexpression of histone H4 alleles associated with silencing defects. These results suggest a direct and specific interaction between Sir2 and H4 in the silencing ...
mechanism.
Mesh Terms:
Genes, Lethal, Histone Deacetylases, Histones, Lysine, Saccharomyces cerevisiae, Silent Information Regulator Proteins, Saccharomyces cerevisiae, Sirtuin 2, Sirtuins, Suppression, Genetic
Genetics
Date: Oct. 01, 2002
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