SIR2-induced inviability is suppressed by histone H4 overexpression.
We have identified histone H4 as a high-expression suppressor of Sir2-induced inviability in yeast cells. Overexpression of histone H3 does not suppress Sir2-induced lethality, nor does overexpression of histone H4 alleles associated with silencing defects. These results suggest a direct and specific interaction between Sir2 and H4 in the silencing ... mechanism.
Mesh Terms:
Genes, Lethal, Histone Deacetylases, Histones, Lysine, Saccharomyces cerevisiae, Silent Information Regulator Proteins, Saccharomyces cerevisiae, Sirtuin 2, Sirtuins, Suppression, Genetic
Genes, Lethal, Histone Deacetylases, Histones, Lysine, Saccharomyces cerevisiae, Silent Information Regulator Proteins, Saccharomyces cerevisiae, Sirtuin 2, Sirtuins, Suppression, Genetic
Genetics
Date: Oct. 01, 2002
PubMed ID: 12399404
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