A novel role of proteasomal β1 subunit in tumorigenesis.
p27Kip1 is a key cell-cycle regulator whose level is primarily regulated by the ubiquitin-proteasome degradation pathway. Its β1 subunit is one of seven β subunits that form the β-ring of the 20S proteasome, which is responsible for degradation of ubiquitinated proteins. We report here that the β1 subunit is up-regulated ... in oesophageal cancer tissues and some ovarian cancer cell lines. It promotes cell growth and migration, as well as colony formation. β1 binds and degrades p27Kip1directly. Interestingly, the lack of phosphorylation at Ser158 of the β1 subunit promotes degradation of p27Kip1. We therefore propose that the β1 subunit plays a novel role in tumorigenesis by degrading p27Kip1.
Mesh Terms:
Carcinogenesis, Cell Movement, Cell Proliferation, Cyclin-Dependent Kinase Inhibitor p27, Esophageal Neoplasms, HEK293 Cells, HeLa Cells, Humans, Phosphorylation, Proteasome Endopeptidase Complex, Protein Binding, Protein Processing, Post-Translational, Proteolysis, Up-Regulation
Carcinogenesis, Cell Movement, Cell Proliferation, Cyclin-Dependent Kinase Inhibitor p27, Esophageal Neoplasms, HEK293 Cells, HeLa Cells, Humans, Phosphorylation, Proteasome Endopeptidase Complex, Protein Binding, Protein Processing, Post-Translational, Proteolysis, Up-Regulation
Biosci. Rep.
Date: Jun. 04, 2013
PubMed ID: 23725357
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