Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death.
Previous genetic studies of the nematode Caenorhabditis elegans identified three important components of the cell death machinery. CED-3 and CED-4 function to kill cells, whereas CED-9 protects cells from death. Here CED-9 and its mammalian homolog Bcl-xL (a member of the Bcl-2 family of cell death regulators) were both found ... to interact with and inhibit the function of CED-4. In addition, analysis revealed that CED-4 can simultaneously interact with CED-3 and its mammalian counterparts interleukin-1beta-converting enzyme (ICE) and FLICE. Thus, CED-4 plays a central role in the cell death pathway, biochemically linking CED-9 and the Bcl-2 family to CED-3 and the ICE family of pro-apoptotic cysteine proteases.
Mesh Terms:
Animals, Apoptosis, Apoptosis Regulatory Proteins, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Calcium-Binding Proteins, Caspase 1, Caspase 8, Caspase 9, Caspases, Cell Line, Cysteine Endopeptidases, Genes, Helminth, Helminth Proteins, Humans, Mutation, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-bcl-2, Transfection, Tumor Cells, Cultured, bcl-X Protein
Animals, Apoptosis, Apoptosis Regulatory Proteins, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Calcium-Binding Proteins, Caspase 1, Caspase 8, Caspase 9, Caspases, Cell Line, Cysteine Endopeptidases, Genes, Helminth, Helminth Proteins, Humans, Mutation, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-bcl-2, Transfection, Tumor Cells, Cultured, bcl-X Protein
Science
Date: Feb. 21, 1997
PubMed ID: 9027312
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