Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia.
Autophagy is a process by which cytoplasmic organelles can be catabolized either to remove defective structures or as a means of providing macromolecules for energy generation under conditions of nutrient starvation. In this study we demonstrate that mitochondrial autophagy is induced by hypoxia, that this process requires the hypoxia-dependent factor-1-dependent ... expression of BNIP3 and the constitutive expression of Beclin-1 and Atg5, and that in cells subjected to prolonged hypoxia, mitochondrial autophagy is an adaptive metabolic response which is necessary to prevent increased levels of reactive oxygen species and cell death.
Mesh Terms:
Animals, Anoxia, Apoptosis Regulatory Proteins, Autophagy, Cell Death, Cytoplasm, Hypoxia-Inducible Factor 1, Membrane Proteins, Mice, Mice, Knockout, Microtubule-Associated Proteins, Mitochondria, Mitochondrial Proteins, Models, Biological, Molecular Conformation, Proteins, Reactive Oxygen Species
Animals, Anoxia, Apoptosis Regulatory Proteins, Autophagy, Cell Death, Cytoplasm, Hypoxia-Inducible Factor 1, Membrane Proteins, Mice, Mice, Knockout, Microtubule-Associated Proteins, Mitochondria, Mitochondrial Proteins, Models, Biological, Molecular Conformation, Proteins, Reactive Oxygen Species
J. Biol. Chem.
Date: Apr. 18, 2008
PubMed ID: 18281291
View in: Pubmed Google Scholar
Download Curated Data For This Publication
167328
Switch View:
- Interactions 2