Evidence that the Rad1 and Rad10 proteins of Saccharomyces cerevisiae participate as a complex in nucleotide excision repair of UV radiation damage.
A newly characterized rad1 missense mutation (rad1-20) in the yeast Saccharomyces cerevisiae maps to a region of the Rad1 polypeptide known to be required for Rad1-Rad10 complex formation. The UV sensitivity of the rad1-20 mutant can be partially and specifically corrected by overexpression of wild-type Rad10 protein. These results suggest ... that complex formation between the Rad1 and Rad10 proteins is required for nucleotide excision repair.
Mesh Terms:
Amino Acid Sequence, Base Sequence, DNA Damage, DNA Repair Enzymes, DNA-Binding Proteins, Dose-Response Relationship, Radiation, Endonucleases, Fungal Proteins, Genes, Fungal, Open Reading Frames, Point Mutation, Restriction Mapping, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Single-Strand Specific DNA and RNA Endonucleases, Ultraviolet Rays
Amino Acid Sequence, Base Sequence, DNA Damage, DNA Repair Enzymes, DNA-Binding Proteins, Dose-Response Relationship, Radiation, Endonucleases, Fungal Proteins, Genes, Fungal, Open Reading Frames, Point Mutation, Restriction Mapping, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Single-Strand Specific DNA and RNA Endonucleases, Ultraviolet Rays
J. Bacteriol.
Date: Oct. 01, 1993
PubMed ID: 8407807
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