Programmed cell death 6 (PDCD6) protein interacts with death-associated protein kinase 1 (DAPk1): additive effect on apoptosis via caspase-3 dependent pathway.

Programmed cell death 6 (PDCD6) protein is a 22 kDa EF-hand type Ca(2+)-binding protein involved in apoptosis. To define the regulating mechanism of PDCD6 activity in the apoptotic pathway, we searched a human ovary cDNA library for a novel PDCD6 binding protein using a yeast two-hybrid system. The selected protein ...
was the human death-associated protein kinase 1 (DAPk1), another protein that functions as a positive mediator of apoptosis. Co-transfection of PDCD6 and DAPk1 cDNA into a tumor cell line accelerated apoptosis via caspase-3 dependent pathway.
Mesh Terms:
Apoptosis, Apoptosis Regulatory Proteins, Calcium-Binding Proteins, Calcium-Calmodulin-Dependent Protein Kinases, Caspase 3, Caspases, Cell Line, Tumor, Death-Associated Protein Kinases, Humans, Protein-Serine-Threonine Kinases, Two-Hybrid System Techniques
Biotechnol. Lett.
Date: Jul. 01, 2005
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