SMS1, a high-copy suppressor of the yeast mas6 mutant, encodes an essential inner membrane protein required for mitochondrial protein import.

MAS6 encodes an essential inner membrane protein required for mitochondrial protein import in the yeast Saccharomyces cerevisiae (Emtage and Jensen, 1993). To identify new inner membrane import components, we isolated a high-copy suppressor (SMS1) of the mas6-1 mutant. SMS1 encodes a 16.5-kDa protein that contains several potential membrane-spanning domains. The ...
Sms1 protein is homologous to the carboxyl-terminal domain of the Mas6 protein. Like Mas6p, Sms1p is located in the mitochondrial inner membrane and is an essential protein. Depletion of Sms1p from cells causes defects in the import of several mitochondrial precursor proteins, suggesting that Sms1p is a new inner membrane import component. Our observations raise the possibility that Sms1p and Mas6p act together to translocate proteins across the inner membrane.
Mesh Terms:
Amino Acid Sequence, Base Sequence, Biological Transport, Active, Carrier Proteins, DNA, Fungal, Fungal Proteins, Gene Deletion, Genes, Fungal, Genes, Suppressor, Intracellular Membranes, Membrane Proteins, Membrane Transport Proteins, Mitochondria, Molecular Sequence Data, Mutation, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid, Sequence Tagged Sites
Mol. Biol. Cell
Date: May. 01, 1994
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