SKN7, a yeast multicopy suppressor of a mutation affecting cell wall beta-glucan assembly, encodes a product with domains homologous to prokaryotic two-component regulators and to heat shock transcription factors.
A search for genes which, at elevated copy number, could suppress the growth defect in a strain disrupted at the KRE9 locus has identified the SKN7 gene. SKN7 was mapped to the right arm of chromosome VIII and is predicted to encode a 70-kDa protein, Skn7p, with a region of ... homology to the DNA binding domain of the Saccharomyces cerevisiae heat shock transcription factor, Hsf1p. Skn7p also has a domain which shows similarity to the prokaryotic receiver modules found on an extensive family of two-component response regulators, including the products of the rcsC and barA genes. SKN7 did not suppress other mutations in the (1-->6)-beta-glucan biosynthetic pathway, suggesting that SKN7 does not act as a general bypass suppressor of this glucan.
Mesh Terms:
Amino Acid Sequence, Base Sequence, Cell Wall, DNA-Binding Proteins, Gene Expression Regulation, Fungal, Genes, Fungal, Genes, Suppressor, Glucans, Heat-Shock Proteins, Molecular Sequence Data, Mutagenesis, Restriction Mapping, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Sequence Deletion, Sequence Homology, Amino Acid, Suppression, Genetic, Transcription Factors
Amino Acid Sequence, Base Sequence, Cell Wall, DNA-Binding Proteins, Gene Expression Regulation, Fungal, Genes, Fungal, Genes, Suppressor, Glucans, Heat-Shock Proteins, Molecular Sequence Data, Mutagenesis, Restriction Mapping, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Sequence Deletion, Sequence Homology, Amino Acid, Suppression, Genetic, Transcription Factors
J. Bacteriol.
Date: Nov. 01, 1993
PubMed ID: 8226633
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