The Saccharomyces cerevisiae SRK1 gene, a suppressor of bcy1 and ins1, may be involved in protein phosphatase function.

The Saccharomyces cerevisiae SRK1 gene, when expressed on a low-copy shuttle vector, partially suppresses the phenotype associated with elevated levels of cyclic AMP-dependent protein kinase activity and suppresses the temperature-sensitive cell cycle arrest of the ins1 mutant. SRK1 is located on chromosome IV, 3 centimorgans from gcn2. A mutant carrying ...
a deletion mutation in srk1 is viable. SRK1 encodes a 140-kDa protein with homology to the dis3+ protein from Schizosaccharomyces pombe. The ability of SRK1 to alleviate partially the defects caused by high levels of cyclic AMP-dependent protein kinase and the similarity of its encoded protein to dis3+ suggest that SRK1 may have a role in protein phosphatase function.
Mesh Terms:
Amino Acid Sequence, Base Sequence, Cloning, Molecular, DNA, Fungal, Genes, Fungal, Genes, Suppressor, Genetic Vectors, Molecular Sequence Data, Open Reading Frames, Phosphoprotein Phosphatases, Plasmids, Restriction Mapping, Saccharomyces cerevisiae, Sequence Homology, Nucleic Acid
Mol. Cell. Biol.
Date: Jun. 01, 1991
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